TAT.ARC: Neuronal Survival Data After Oxygen-Glucose Deprivation

Stefan Donath's dataset measures lactate dehydrogenase activity as a marker of cell death in primary cortical neurons subjected to 150 minutes of oxygen-glucose deprivation. The data likely contains results from experiments where neurons were transduced with lentiviral particles for ARC knockdown or treated with TAT proteins. The dataset is associated with an open-access research paper on the paperswithcode platform.

Use Cases

• Modeling the impact of ARC protein transduction on neuronal survival based on the described experimental treatment.
• Analyzing the relationship between lactate dehydrogenase release and cell death under oxygen-glucose deprivation conditions.
• Comparing cell death outcomes between ARC knockdown and non-targeting control groups as described in the experiment.

Strengths

• Data is derived from a controlled laboratory experiment with a defined 150-minute oxygen-glucose deprivation protocol.
• The dataset is linked to an open-access research paper, providing context for the experimental methods.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset description is specific to one experimental setup; generalizability may be limited.

Provenance

Source

Stefan Donath via paperswithcode

Collection Method

Laboratory experiment measuring lactate dehydrogenase activity in primary neuronal cultures.