TCR Repertoires of Melanoma Patient TILs Under Various Stimulation Conditions

T-cell receptor sequences from a single melanoma patient's tumor-infiltrating lymphocytes, sorted by CD39 and PD-1 expression. The data includes repertoires from bulk TILs expanded for 9 days and from CD137-positive TILs re-stimulated with melanoma tumor-associated antigens. Author Mikhail Goncharov published the 38.9 MB dataset on figshare under a CC-BY-4.0 license, with a last update timestamp of 2026-05-26.

Use Cases

• Compare TCR repertoires between CD39+ PD-1+ and other TIL subsets based on the described cell sorting.
• Analyze the impact of in vitro expansion and antigen re-stimulation on T-cell clonal diversity mentioned in the description.
• Identify shared or enriched TCR sequences in response to melanoma tumor-associated antigen stimulation.
• Benchmark computational tools for TCR repertoire analysis using a dataset from a defined clinical sample.

Strengths

• Data is focused on a specific, clinically relevant cell population (CD8+ CD39+ PD-1+ TILs) from melanoma metastases.
• Includes multiple experimental conditions (bulk expansion, antigen re-stimulation) for comparative analysis.
• Available under a permissive CC-BY-4.0 license for reuse and redistribution.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a single patient (mp26), limiting generalizability.

Provenance

Source

figshare, author Mikhail Goncharov.

Collection Method

Likely derived from sequencing sorted TIL populations from melanoma patient lymph node metastases.

Freshness

Last updated 2026-05-26 18:44:10; freshness should be verified.