Tenofovir Disoproxil Fumarate HbF Induction Data from K562 Cells and Mouse Models

Preclinical research data investigates Tenofovir disoproxil fumarate (TDF) as a fetal hemoglobin (HbF) inducing agent for treating β-hemoglobinopathies. The study includes results from human erythroid K562 cell line experiments and a β-YAC transgenic mouse model, measuring γ-globin gene expression and HbF production. The dataset is published on Papers with Code under an Open Access license.

Use Cases

• Analyzing drug-induced γ-globin gene transcription changes based on RT-qPCR data mentioned in the description
• Modeling fetal hemoglobin (HbF) expression levels based on flow cytometry and immunofluorescence microscopy results
• Evaluating drug cytotoxicity profiles at HbF-inducing concentrations as described in the study
• Comparing in vitro (K562 cells) and in vivo (β-YAC mice) HbF induction efficacy for drug candidate screening

Strengths

• Data is derived from both a human cell line (K562) and an in vivo transgenic mouse model (β-YAC), providing complementary evidence
• Study reports a significant increase in γ-globin gene transcription and HbF expression mediated by TDF
• TDF showed no cytotoxic effect at HbF inducing concentrations, a key safety finding

Limitations

• Row count and dataset size are unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect the specific experimental bias inherent to the paperswithcode platform and the single study

Provenance

Source

Papers with Code

Collection Method

Experimental data from laboratory studies, including benzidine/H2O2 reaction, plasma hemoglobin assay, RT-qPCR, flow cytometry, and immunofluorescence microscopy.