Terpenoids from <i>Euphorbia ebracteolata</i> (Hayata.) with their multidrug resistance re

Thirteen terpenoid compounds, including one previously undescribed ursane-type triterpenoid, were isolated from the plant Euphorbia ebracteolata Hayata. Their structures were determined using spectroscopic methods like NMR and HRESIMS, and their absolute configuration was elucidated via ECD calculations. All compounds were screened for cytotoxicity and reverse multidrug resistance activity, with one compound showing potential inhibitory activity against adriamycin-sensitive HepG-2 cells.

Use Cases

• Screen for cytotoxic activity based on IC50 values against HepG-2 cells.
• Evaluate multidrug resistance reversal potential based on reversal factor (RF) scores.
• Analyze structure-activity relationships among diterpenes and triterpenoids.
• Identify novel chemical scaffolds for drug discovery based on spectroscopic characterization data.

Strengths

• Includes one previously undescribed ursane-type triterpenoid (euperata A).
• Reports specific IC50 value (5.66 ± 1.15 μM) for compound 1 against Adr-sens HepG2.
• Provides reversal factor (RF) values for four compounds (5, 8, 10, 11) ranging from 11.38 to 86.23.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect the specific experimental bias inherent to the single-source plant material.

Provenance

Source

Jia-Le Liu via figshare.

Collection Method

Compounds were obtained from Euphorbia ebracteolata Hayata and characterized via spectroscopic analysis and ECD calculations.

Freshness

Last updated 2026-05-11 20:40:03; freshness should be verified.