Adenosine Receptor C-Terminus Signaling Data from Yeast and Mammalian Assays

Tulane University research led by Abhinav R. Jain investigates the role of the C-terminus in adenosine receptor signaling. The dataset likely contains results from yeast MAPK response-based fluorescence assays and mammalian cell (HEK-293) cAMP-linked signaling experiments comparing full-length A1R and A2AR receptors with their truncated variants. It supports findings that the C-terminus is essential for G-protein activation but not for signaling specificity.

Use Cases

• Training models to predict G-protein coupling based on receptor structural features mentioned in the description
• Analyzing the impact of C-terminal truncations on downstream signaling outputs from yeast and mammalian assays
• Validating computational models of receptor-protein interactions for drug target validation

Strengths

• Data is derived from controlled experimental assays in both yeast and mammalian (HEK-293) cell systems
• Findings are directly relevant to structure-based drug design for adenosine receptors, as stated in the description

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

Tulane University

Collection Method

Experimental data from yeast MAPK fluorescence assays and mammalian cell signaling experiments