Pediatric Iron Deficiency Anemia and Serum Trace Elements Meta-Analysis

Maryam Mobasheri-Shiri's systematic review and meta-analysis investigates the association between serum trace elements and iron deficiency anemia in children and adolescents. The work includes eight articles, twelve datasets, and 1105 participants, with literature searched up to January 2025. The study protocol was registered with PROSPERO (CRD42024578704).

Use Cases

• Analyzing pooled weighted mean differences for trace elements like Fe, Zn, Cu, and Mg based on the meta-analysis results.
• Investigating heterogeneity and subgroup trends across age, gender, and geography based on the described statistical analyses.
• Informing nutritional intervention strategies for pediatric anemia based on the identified alterations in trace element levels.

Strengths

• Includes 1105 participants from eight articles, providing a quantitative synthesis.
• Reports specific pooled weighted mean differences with 95% confidence intervals for four trace elements.
• Conducted subgroup, sensitivity, and publication bias analyses as described.
• Study protocol was pre-registered (PROSPERO CRD42024578704).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• High heterogeneity (I² > 95%) was noted for Fe, Zn, and Cu, indicating variability in the underlying studies.

Provenance

Source

figshare, author Maryam Mobasheri-Shiri

Collection Method

Systematic review and meta-analysis of observational studies from PubMed, Scopus, Embase, and Web of Science.

Time Range

Literature search up to January 2025.

Freshness

Last updated 2026-04-28 03:27:19; freshness should be verified.

Geography

Global, as indicated by the inclusion of studies across different geographies in subgroup analysis.