IL-24 in Sepsis: Mouse Model Data on Bacterial Dissemination and Inflammation

Experimental data from a study investigating the role of interleukin-24 (IL-24) in Escherichia coli-induced sepsis. The dataset includes results from in vitro and in vivo experiments with wild-type and IL-24 knockout mice, measuring survival, bacterial load, and immune cell infiltration. It was authored by Jinjin Lu and last updated in June 2026.

Use Cases

• Validate the pathogenic role of IL-24 in sepsis based on survival and bacterial load data from knockout mice.
• Analyze the effect of recombinant IL-24 protein on bacterial accumulation and leukocyte chemotaxis as described in the in vitro and in vivo experiments.
• Assess the therapeutic potential of IL-24 inhibition for sepsis treatment based on the reported reduction in mortality.

Strengths

• Dataset size is 108.8 MB, indicating a medium-scale collection of experimental results.
• Includes data from both in vitro and in vivo experimental models, as described in the study.
• Released under the permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• Data files are in TIF, DOCX, and PDF formats, requiring specific tools for analysis and integration.

Provenance

Source

figshare

Collection Method

Experimental data from a research study on sepsis pathogenesis.

Freshness

Last updated 2026-06-02 20:40:10; freshness should be verified.