Meta-Analysis of Immunomodulatory Diet Effects on ICU Patient Outcomes

A systematic review and meta-analysis by Mahsa Malekahmadi of Mashhad University of Medical Sciences, published by September 2019. It aggregates data from 10 Randomized Controlled Trials (RCTs) involving 1,166 critically ill patients. The study examines the impact of an enteral immunomodulatory diet containing omega-3 fatty acid, γ-linolenic acid, and antioxidants on clinical outcomes in intensive care units.

Use Cases

• Training models to predict ICU length of stay based on nutritional intervention data.
• Analyzing the effect of specific dietary components on mortality rates in critically ill populations.
• Conducting secondary meta-analyses on the relationship between immunomodulatory formulas and organ failure scores.
• Benchmarking clinical trial outcomes for new nutritional therapies in intensive care.

Strengths

• Aggregates data from 10 distinct Randomized Controlled Trials (RCTs).
• Includes results for 1,166 total participants.
• Reports specific quantitative outcomes like weighted mean differences and relative risks with confidence intervals.

Limitations

• The underlying raw patient-level data is not provided; only aggregated meta-analysis results are available.
• Column-level documentation and sample data are absent, limiting direct usability for ML.
• The last update date is unknown, so the findings may not include the most recent research.

Provenance

Source

Mahsa Malekahmadi, Mashhad University of Medical Sciences

Collection Method

Systematic review and meta-analysis of RCTs sourced from PubMed, Scopus, and ISI Web of Knowledge.

Time Range

Literature searched until September 2019.