Biomarker Data from FTC/TDF Treatment in Diet-Induced Prediabetic Rats

Twenty-eight male Sprague-Dawley rats were studied over a 32-week period involving diet-induced prediabetes and subsequent drug treatment. This dataset contains biochemical measurements of 18 parameters, including vascular endothelial growth factor, nitric oxide, lipid profile, and inflammatory cytokines, collected for a master's dissertation. The data was uploaded by Khanyisa Maswanganyi on April 22, 2026.

Use Cases

• Analyzing the impact of FTC/TDF on glucose tolerance based on oral glucose tolerance test results
• Investigating drug effects on endothelial function based on measurements of endothelin-1 and nitric oxide synthase
• Studying inflammatory response to treatment based on tumor necrosis factor alpha and interleukin levels
• Assessing oxidative stress and antioxidant capacity based on hydrogen peroxide and malondialdehyde measurements
• Correlating cardiac risk markers with metabolic parameters based on cardiac troponin I and heart-to-body weight ratios

Strengths

• Includes 18 distinct biochemical and physiological parameters measured in a controlled animal study
• Data collection followed a defined 20-week diet induction and 12-week treatment protocol
• Dataset is openly available under a CC-BY-4.0 license for reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small at 59.5 KB, indicating limited scope

Provenance

Source

figshare

Collection Method

Biochemical analysis using colorimetric assays on samples from a controlled animal experiment.

Time Range

Study period implied by experimental protocol (32 weeks total).

Freshness

Last updated 2026-04-22 14:11:38; freshness should be verified

Geography

Laboratory study; geographic location is unknown.