Ty-BatCoV-HKU4 Entry Pathway Data for Huh7 Cells

A 218.3 MB dataset supports research confirming the pH-dependent endo/lysosomal entry pathway of Tylonycteris bat coronavirus HKU4 into Huh7 cells. It was contributed by author Longchao Zhu and last updated in April 2026. The data provides evidence for the roles of caveolin, dynamin, PI3K, and actin in viral entry.

Use Cases

• Validate the role of caveolin and dynamin in viral entry using specific protein inhibition or localization data.
• Analyze pH-dependency of infection through time-series data of viral entry under different pH conditions.
• Correlate PI3K and actin activity measurements with viral entry efficiency to confirm pathway requirements.
• Compare entry kinetics of Ty-BatCoV-HKU4 with other coronaviruses using provided infection assay results.

Strengths

• Data volume of 218.3 MB suggests inclusion of detailed experimental results.
• Explicitly linked to a specific, peer-reviewed research finding on viral entry mechanisms.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Unknown row count and specific column structure limits immediate usability.
• Data scope is narrowly focused on a single virus (Ty-BatCoV-HKU4) and cell line (Huh7).
• Sample data and file descriptions within the ZIP archive are unavailable for preview.

Provenance

Source

Longchao Zhu, via the figshare repository.

Collection Method

Experimental data generated to support the specific research paper on viral entry pathways.

Freshness

Last updated in April 2026.