The incidence, maternal, fetal and neonatal consequences of single intrauterine fetal deat

81 monochorionic twin pregnancies with single intrauterine fetal death after 14 weeks gestation were studied prospectively. Data on aetiology, co-twin survival, CNS imaging, and maternal outcomes were collected via the UK Obstetric Surveillance System (UKOSS). The study was conducted by researchers at the University of Birmingham and published as an open-access paper.

Use Cases

• Predicting adverse neurological outcomes for the surviving co-twin based on antenatal imaging findings.
• Analyzing the association between twin-twin transfusion syndrome and single intrauterine fetal death.
• Studying rates of preterm birth and its causes (spontaneous vs. iatrogenic) following a single fetal demise.
• Investigating the incidence of major maternal morbidity, such as infection requiring ITU admission.
• Evaluating post-mortem findings to classify causes of death in twin pregnancies.

Strengths

• Prospective observational design focused on 81 specific cases.
• Reports specific outcome rates, such as 47% of cases attributed to twin-twin transfusion syndrome and a 14% co-twin mortality rate.
• Includes detailed measures for both fetal/neonatal (CNS imaging, gestation at delivery) and maternal outcomes.

Limitations

• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• Sample size of 81 pregnancies may limit statistical power for some subgroup analyses.
• Antenatal CNS imaging was not performed in all cases, with results known for only 33 of the 46 cases imaged.

Provenance

Source

University of Birmingham via UK Obstetric Surveillance System (UKOSS).

Collection Method

Prospective observational study using data collection forms submitted by UKOSS reporters from hospital records.

Geography

United Kingdom