Rat and Hamster Liver Proteome with 8,500+ Proteins and 15 CYP Quantifications

More than 8,500 proteins were quantified in rat and hamster liver S9 fractions under basal and induced conditions. The dataset, created by Jasjot Singh and last updated in June 2026, integrates global proteomic profiling with absolute quantification of 15 cytochrome P450 enzymes. It serves as a reference for drug metabolism, pharmacokinetics, and toxicology studies.

Use Cases

• Modeling species-specific cytochrome P450 induction responses based on global proteomic changes.
• Calibrating in vitro systems for drug metabolism studies using absolute CYP quantification data.
• Investigating proteostasis network activation based on heat-shock chaperone levels mentioned in the description.
• Comparing xenobiotic pathway remodeling between rats and hamsters under different chemical inducers.

Strengths

• Quantifies more than 8,500 proteins across experimental conditions.
• Includes absolute quantification for 15 specific cytochrome P450 enzymes using stable isotope-labeled standards.
• Compares two species (rat and hamster) under multiple induction regimes (Aroclor 1254 and PBNF).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 11.1 KB, indicating limited scope or highly summarized data.

Provenance

Source

figshare

Collection Method

Global proteomic profiling and targeted mass spectrometry with stable isotope-labeled standards.

Freshness

Last updated 2026-06-02 09:32:16; freshness should be verified.