Mouse Abdominal Aortic Aneurysm mRNA-seq Data with Necroptosis and Immune Gene Analysis

157.1 MB of bulk RNA-sequencing data from mouse aortae, generated by author Hongming Shao and last updated on 2026-04-20. The dataset was used to investigate necroptosis activation and immune response modulation in abdominal aortic aneurysm (AAA) tissues. It includes findings on upregulated genes like RIPK3 and MLKL, as well as changes in immunoglobulin and inflammatory signaling genes.

Use Cases

• Validate necroptosis pathway activation in AAA based on the reported upregulation of RIPK3 and MLKL.
• Analyze immune and inflammatory gene expression shifts described in the dataset, such as changes in Igkv1-9 and IL-10 family genes.
• Train models to classify AAA disease states using transcriptomic profiles from the sequencing data.
• Investigate the therapeutic effect of PTL on inflammatory balance as suggested by the gene expression results.

Strengths

• Data is focused on a specific disease model (mouse AAA) with clear biological findings reported, such as fold changes >3 for RIPK3 and MLKL.
• Released under a permissive CC0-1.0 license, allowing for unrestricted reuse.
• File size of 157.1 MB suggests a medium-scale dataset suitable for detailed analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain modeling tasks.
• The description is specific to the original study's findings; the raw data's structure and completeness require manual inspection.

Provenance

Source

figshare, author Hongming Shao

Collection Method

Bulk RNA-sequencing performed on mouse aortae from different experimental groups.

Time Range

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Freshness

Last updated 2026-04-20 02:49:51; freshness should be verified.

Geography

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