Lung N‑Glycoproteome in a Rat Model of Pulmonary Arterial Hypertension

A proteomic and N-glycoproteomic analysis of lung tissue from a monocrotaline-induced pulmonary arterial hypertension (PAH) rat model. The dataset, authored by Guili Lian and last updated in June 2026, includes quantitative data for 7,048 proteins and 1,918 N-glycosylation sites, with 1,302 proteins and 320 glycosylation sites showing differential expression.

Use Cases

• Identify dysregulated glycoproteins and pathways based on the 1,302 differentially expressed proteins and 320 dysregulated glycosylation sites.
• Analyze glycoprotein motif localization based on the described enrichment in plasma membrane and extracellular proteins.
• Investigate integrated multiomics relationships based on the 805 overlapping candidates identified from proteomic and glycoproteomic data.
• Validate potential therapeutic targets based on confirmed increases in proteins like VCAM1 and AMBP mentioned in the description.

Strengths

• Includes quantitative data for 7,048 proteins and 1,918 N-glycosylation sites, providing a system-wide view.
• Identifies 1,302 differentially expressed proteins and 320 dysregulated glycosylation sites for focused analysis.
• Results are integrated from both proteomic and site-specific N-glycoproteomic analyses.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a specific rat model (monocrotaline-induced PAH), which may limit direct translation to human disease.

Provenance

Source

figshare

Collection Method

Quantitative LC-MS/MS with glycoprotein enrichment performed on lung tissues from a monocrotaline-induced PAH rat model.

Time Range

Experimental timeframe not specified in metadata.

Freshness

Last updated 2026-06 13:09:24; freshness should be verified.

Geography

Laboratory study; geographic origin not specified.