Lung N-Glycoproteome in a Rat Model of Pulmonary Arterial Hypertension

Guili Lian's dataset provides an integrated proteomic and N-glycoproteomic analysis of lung tissues from a monocrotaline-induced pulmonary arterial hypertension rat model. The data includes 7,048 identified proteins, 1,302 differentially expressed proteins, and 1,918 N-glycosylation sites across 764 glycoproteins, with 320 sites showing significant dysregulation. The dataset was last updated on June 3, 2026.

Use Cases

• Identify dysregulated glycoproteins and glycosylation sites based on the 320 significantly altered sites from 260 glycoproteins.
• Analyze pathway enrichment based on bioinformatics results for ribosome, lysosome, TGF-β signaling, and mineral absorption pathways.
• Investigate protein-protein interactions and extracellular matrix dysfunction based on described alterations in integrin binding and ECM-receptor interaction.
• Validate potential biomarkers like VCAM1 and AMBP using the provided quantitative proteomic and glycoproteomic data.

Strengths

• Includes 7,048 identified proteins and 1,918 N-glycosylation sites, providing a system-wide view.
• Quantifies 1,302 differentially expressed proteins and 320 significantly dysregulated glycosylation sites for comparative analysis.
• Integrates proteomic and site-specific N-glycoproteomic data from 7,136 and 2,897 proteins respectively, identifying 805 overlapping candidates.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is derived from a specific monocrotaline-induced rat model, which may limit generalizability to other PAH models or human disease.

Provenance

Source

figshare, author Guili Lian

Collection Method

Integrated proteomic and site-specific N-glycoproteomic analysis using quantitative LC-MS/MS with glycoprotein enrichment on lung tissues from a monocrotaline-induced PAH rat model.

Freshness

Last updated 2026-06-03 13:09:24; freshness should be verified.