Rat Lung N‑Glycoproteome in Monocrotaline-Induced Pulmonary Hypertension

7,048 proteins and 1,918 N‑glycosylation sites identified in lung tissues from a monocrotaline-induced pulmonary arterial hypertension rat model. The dataset, created by Guili Lian and last updated in June 2026, includes 1,302 differentially expressed proteins and 320 dysregulated glycosylation sites. It provides a system-wide view of protein N‑glycosylation alterations in this disease model.

Use Cases

• Identify dysregulated glycoproteins and pathways based on the 1,302 differentially expressed proteins and 320 dysregulated glycosylation sites.
• Analyze protein localization patterns based on the enriched localization in plasma membrane and extracellular proteins mentioned in the description.
• Investigate pathway alterations such as ribosome downregulation and lysosome upregulation based on the bioinformatics results.
• Explore integrated multiomics relationships based on the 805 overlapping candidates identified from proteome and N‑glycoproteome analysis.

Strengths

• Includes 7,048 identified proteins and 1,918 N‑glycosylation sites, providing a quantitative foundation.
• Contains 1,302 differentially expressed proteins and 320 dysregulated glycosylation sites, highlighting specific alterations.
• Integrated analysis of 7,136 proteome and 2,897 N‑glycoproteome proteins identified 805 overlapping candidates.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is derived from a specific monocrotaline-induced rat model; applicability to other models or human PAH may be limited.

Provenance

Source

figshare

Collection Method

Integrated proteomic and site-specific N‑glycoproteomic analysis using quantitative LC‑MS/MS with glycoprotein enrichment on lung tissues.

Time Range

Not specified in the input.

Freshness

Last updated 2026-06-03 13:09:20; freshness should be verified.

Geography

Not specified in the input.