NPD2560: Chemical-Genomic and Transcriptomic Data on Antifungal Mechanism

WEI LIU published a dataset on figshare in April 2026, detailing the antifungal agent NPD2560. The 9.8 MB dataset contains results from chemical-genomic profiling, mutational analyses, biochemical assays, and transcriptomic analysis in Saccharomyces cerevisiae and Candida krusei. It provides evidence for the compound's mechanism of action targeting the Rho1-centered cell wall regulatory network.

Use Cases

• Identify genetic determinants of drug sensitivity based on chemical-genomic profiling data.
• Analyze cell wall stress responses based on transcriptomic data for genes like CRH1, KDX1, CWP1, and PIR3.
• Investigate biochemical perturbations in glucan levels based on the described reduction in β-(1,6)-glucan.
• Study compensatory cell wall remodeling based on data on chitin deposition and cell-wall integrity pathway activation.

Strengths

• Dataset is 9.8 MB in size, indicating a focused and manageable download.
• License is CC-BY-4.0, allowing for open sharing and reuse.
• Last updated on 2026-04-22, suggesting recent data.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

WEI LIU via figshare

Collection Method

Chemical-genomic profiling, mutational analysis, biochemical assays, and transcriptomic analysis.

Time Range

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Freshness

Last updated 2026-04-22 05:48:22; freshness should be verified.

Geography

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