Cardiac Transcriptome Data on ROR-alpha Regulation Including Adra1a

Transcriptomic data from a study investigating the role of the nuclear receptor ROR-alpha in mouse cardiomyocytes. The dataset, authored by Brian Jensen and last updated in May 2026, includes findings on ROR-alpha's regulation of sarcomeric genes and the alpha-1A adrenergic receptor (Adra1a). It comprises 49.3 MB of data files in formats including PDF, PRISM, and XLSX.

Use Cases

• Identify transcriptional targets of ROR-alpha in cardiomyocytes based on transcriptomic comparisons.
• Study the relationship between ROR-alpha and sarcomeric gene expression programs mentioned in the description.
• Investigate the direct transcriptional regulation of the Adra1a gene as described in the study.
• Analyze the effect of hypoxia on ROR-alpha-mediated gene regulation referenced in the findings.

Strengths

• Data is associated with a published study using transcriptomics and genetic/pharmacologic validation.
• Includes multiple analysis-ready file formats (XLSX, PRISM).
• Released under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 49.3 MB size suggests a small dataset, potentially limiting scope.

Provenance

Source

figshare

Collection Method

Transcriptomic analysis of mouse heart tissue from wild-type and RORa-deficient models.

Freshness

Last updated 2026-05-13 19:19:42; freshness should be verified.