Rat Study on Whortleberry Extract Protecting Hearing from Cisplatin Ototoxicity

Forty-eight male rats were used in an experimental study investigating the protective effects of whortleberry extract. The research, authored by Doğukan Özdemir, involved audiologic testing via Distortion Product Otoacoustic Emission and biochemical analysis of blood and cochlear tissue. Results indicated that whortleberry extract protects hearing against cisplatin-induced ototoxicity.

Use Cases

• Train models to predict otoprotective efficacy based on biochemical parameters mentioned in the description.
• Analyze dose-response relationships for natural extracts against drug-induced hearing loss.
• Benchmark experimental results for oxidative stress markers in cochlear tissue from animal models.

Strengths

• Study design includes a control group and multiple treatment groups for comparison.
• Audiologic and histopathological endpoints provide multi-faceted outcome measures.
• Biochemical parameters related to oxidative stress are measured, offering mechanistic insights.

Limitations

• Row count and specific column-level data are unknown, limiting suitability assessment.
• The dataset is derived from a single animal study, which may limit generalizability.
• Last update date and detailed data documentation are unavailable.

Provenance

Source

Doğukan Özdemir

Collection Method

Experimental study on rats, including audiologic tests, blood sampling, and histopathological examination.