PI3K Subunits and BRD7 Insulin Signaling: Mouse Metabolic Phenotypes

Metabolic phenotype measurements and protein quantification data from mouse models and cell-based assays investigating insulin signaling. Produced by Sang Won Park and published via Harvard Dataverse in 2026, the data tracks the differential effects of PI3K subunits p85α and p85β on BRD7-mediated glucose homeostasis.

Use Cases

• Analyzing the impact of p85 isoform deletion on Glucose Tolerance Test (GTT) and Insulin Tolerance Test (ITT) results
• Correlating BRD7 expression levels with Western blot densitometry quantification of insulin signaling components
• Modeling the relationship between body weight and fasting/fed blood glucose levels under specific genetic modifications

Strengths

• Includes multi-modal metabolic data from GTT, ITT, and PTT assays
• Combines in vivo mouse model phenotypes with in vitro cell-based signaling data
• Provides quantitative Western blot densitometry for molecular-level signaling analysis

Limitations

• Sample size for mouse cohorts and cell replicates is not specified in the metadata
• Lack of column headers or data dictionary in the provided summary makes initial interpretation difficult
• Specific to a narrow biological pathway (PI3K/BRD7), limiting generalizability to other metabolic disorders

Provenance

Source

Park, Sang Won via Harvard Dataverse

Collection Method

Laboratory experiments (mouse models and cell-based assays)

Freshness

Last updated March 2026