Mouse Cartilage Response to 30 Days of Microgravity on BION-M1

National Aeronautics and Space Administration (NASA) data characterizes articular and sterno-costal cartilages from skeletally-mature mice flown for 30 days on the BION-M1 mission. Samples were analyzed histologically for proteoglycan loss and at the gene expression level using Affymetrix gene arrays. The dataset was last updated on March 13, 2026.

Use Cases

• Identify gene expression changes in cartilage due to microgravity based on Affymetrix array data.
• Quantify proteoglycan loss in articular and sterno-costal cartilages from histological characterization.
• Compare tissue response between different cartilage types (articular vs. sterno-costal) after spaceflight.
• Model biological impacts of long-duration microgravity on skeletal health using a mouse model.

Strengths

• Data originates from a controlled spaceflight experiment on the BION-M1 mission.
• Includes both histological and gene expression analysis for a multi-modal view.
• Samples are from skeletally-mature mice, providing a model for adult tissue response.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is provided in a BIN file format, which may require specialized tools to access.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Cartilage samples were isolated from mice flown on the BION-M1 space mission and characterized histologically and via gene arrays.

Freshness

Last updated 2026-03-13 19:34:22.420955; freshness should be verified.