Gut Microbiota, Air Pollution, and Cognitive Function Data for 1,027 Older Adults

A dataset from a study of 1,027 older adults, published by Wenhao Qi in April 2026, exploring the mediating role of gut microbiota and metabolites in the link between air pollution and cognitive decline. It includes metagenomic and metabolomic profiles, estimated PM2.5 and O3 exposures, and cognitive assessments. The data is stored in an XLSX file.

Use Cases

• Training models to predict cognitive outcomes based on microbial and metabolite profiles.
• Analyzing associations between specific bacterial taxa (e.g., Blautia obeum) and air pollution levels.
• Investigating the role of functional pathways like 2-oxoglutarate metabolism in mediating environmental effects.
• Replicating statistical mediation analyses using microbial and metabolite data.

Strengths

• Includes data from 1,027 older adults, providing a substantial sample size.
• Integrates multiple data types: gut microbiome (bacteria/fungi), 195 circulating metabolites, and satellite-modeled air pollution estimates.
• Statistical analyses were performed with a defined false discovery rate threshold of 0.25.
• Findings were partially validated in an independent population.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is small at 102.4 KB, indicating limited scope or highly summarized content.
• Geographic scope of the participant population is not specified, which may limit generalizability.

Provenance

Source

figshare, author Wenhao Qi.

Collection Method

Data gathered from metagenome and internal transcribed spacer sequencing, targeted metabolomics, and satellite-based air pollution modeling.

Time Range

null

Freshness

Last updated 2026-04-23 13:03:36; freshness should be verified.

Geography

null