R-Loops Systematic Review: 71 Studies on Epigenetics and Genome Stability

A systematic review synthesizing evidence on R-loops, epigenetic regulation, and genome stability. The review, following PRISMA guidelines, analyzed 1290 articles from PubMed and ScienceDirect up to January 2026, with 71 studies meeting inclusion criteria. It was authored by Zi Hao Jiang and last updated in April 2026.

Use Cases

• Analyze relationships between R-loops and DNA methylation based on described DNMT/TET enzyme interactions
• Investigate R-loop roles in 3D genome architecture based on described associations with TAD boundaries and LLPS
• Study disease pathogenesis links based on described dysregulation of R-loop homeostasis
• Benchmark epigenomic profiling techniques based on the mention of integrating DRIP-seq with functional tests

Strengths

• Follows PRISMA guidelines with a registered protocol (INPLASY202560055)
• Includes 71 studies from a screened pool of 1290 articles
• Methodological rigor assessed using a modified SYRCLE risk-of-bias tool

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is 36.0 KB, indicating a very limited scope focused on review metadata

Provenance

Source

figshare, authored by Zi Hao Jiang

Collection Method

Systematic literature review of PubMed and ScienceDirect databases

Time Range

Literature search conducted through 18 January 2026

Freshness

Last updated 2026-04-13 13:31:08; freshness should be verified

Geography

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