Cystatin C Sex Difference Meta-Analysis Across Age Groups

Over 46,000 healthy adults from 21 studies were analyzed in a PRISMA-compliant systematic review and meta-analysis. The dataset contains extracted data from 52 unique subgroups, revealing an 8.6% higher cystatin C concentration in men under 60 years old, with the difference attenuating with age. It was authored by Filip Landgren and published by Taylor & Francis in March 2026.

Use Cases

• Calibrating sex-adjustment factors in cystatin C-based GFR equations using the pooled male-to-female ratio estimates.
• Modeling the age-dependent attenuation of the cystatin C sex difference via the reported meta-regression coefficient (β = -0.0011 per year).
• Assessing heterogeneity in biomarker studies by examining the reported I² statistics (98% for younger, 76% for older adults).
• Validating systematic review methodologies using the provided PRISMA-compliant search strategy and sensitivity analysis results (leave-one-out, trim-and-fill).

Strengths

• Analysis is based on a large sample of over 46,000 healthy adults aggregated from 21 independent studies.
• The review followed a PRISMA-compliant methodology and performed multiple sensitivity analyses to confirm result robustness.
• The dataset provides specific, quantitative estimates like the 8.6% sex difference for adults under 60 and the annual attenuation rate.

Limitations

• The exact row count and column schema are not provided by any source, limiting precise data structure understanding.
• Substantial between-study heterogeneity (I² up to 98%) is reported, indicating variability in underlying population characteristics and methods.

Provenance

Source

Filip Landgren, published via Taylor & Francis.

Collection Method

PRISMA-compliant systematic review and meta-analysis of studies from PubMed, Scopus, and Embase.

Time Range

Life-course context from pediatric data through older adults (age ≥ 60 years).

Freshness

2026-03-25 07:55:55

Geography

null