JV-GL1: Intraocular Pressure Response Data in Mouse Models

Experimental data from a study investigating the role of EP2 receptors in mediating the long-term intraocular pressure reduction of drug JV-GL1. The research was conducted by Jacques Bertrand of Imperial College London using C57BL/6J and EP2 receptor knock-out mice under both normotensive and steroid-induced ocular hypertensive conditions. Measurements include tonometric intraocular pressure readings and ex vivo aqueous humor outflow facility assessments.

Use Cases

• Validate the EP2 receptor dependency of drug action based on comparative data from wild-type and knock-out mice.
• Model the duration of intraocular pressure reduction based on the described 4-6 day effect in steroid-induced ocular hypertensive wild-type mice.
• Investigate the relationship between aqueous humor outflow facility and intraocular pressure changes based on ex vivo perfusion experiments.

Strengths

• Data is derived from controlled experiments using specific genetic models (C57BL/6J and EP2KO mice).
• Study includes both normotensive and a disease model (steroid-induced ocular hypertensive mice).
• Measurements include both in vivo tonometry and ex vivo perfusion facility.

Limitations

• Row count and specific column-level data are unknown, limiting suitability assessment.
• Dataset size and file formats are unspecified, complicating integration planning.
• Last update date is unknown; freshness unverified.

Provenance

Source

Imperial College London

Collection Method

Laboratory experiments on mice, including tonometric IOP measurement and iPerfusion system outflow facility assessment.