Systematic Review of Potassium Citrate Therapy Effects on 24-Hour Urine Profiles

A systematic review and meta-analysis synthesizes results from eight clinical studies evaluating changes in 24-hour urine parameters in patients with urolithiasis receiving potassium citrate therapy. The dataset includes study-level changes in diuresis, pH, citrate, oxalate, and other urinary components. The work was conducted by the EAU-YAU urolithiasis working group and published on figshare in 2026.

Use Cases

• Meta-analyzing the effect of potassium citrate on urinary pH based on the reported ΔpH values.
• Investigating the relationship between therapy and urinary citrate excretion based on the reported Δcitrate values.
• Assessing the variability in therapeutic response across different patient cohorts and doses as described in the review.
• Evaluating changes in urinary oxalate levels in response to alkali therapy based on the reported Δoxalate value.

Strengths

• Follows PRISMA guidelines and a registered protocol (PROSPERO CRD420261282247).
• Includes data from eight studies containing nine patient groups.
• Reports specific quantitative changes, such as an average diuresis increase of 0.21 L/day and a ΔpH of +0.64.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The authors note substantial between-study heterogeneity and a small number of studies limit inference for several parameters.
• The data file is a 778.2 KB PDF, which is a small, document-based format requiring extraction for analysis.

Provenance

Source

figshare

Collection Method

Systematic literature review and multilevel meta-analysis of clinical studies.

Freshness

Last updated 2026-05-10 18:00:03; freshness should be verified.