Pioglitazone Effects on Severe Acute Pancreatitis in Rats

54 Sprague Dawley rats were used to investigate the therapeutic effect of pioglitazone on severe acute pancreatitis. The study measured serum amylase, pro-inflammatory cytokines, pancreatic myeloperoxidase activity, and Card9/NF-κB/p38MAPK expression at 3, 6, and 12 hours post-induction. The dataset was generated by author Hai Wang and is associated with an open-access research paper.

Use Cases

• Train models to predict therapeutic outcomes based on serum amylase and cytokine levels mentioned in the description
• Analyze correlations between Card9 expression and pancreatic histological damage scores described in the study
• Study the time-course effects of drug intervention using measurements taken at 3, 6, and 12-hour intervals

Strengths

• Data is derived from a controlled experiment with 54 animal subjects
• Multiple time points (3, 6, 12 hours) provide a longitudinal view of the disease and treatment response
• Includes multiple measurement types: pathological scoring, enzyme assays, and molecular expression data

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect the specific experimental bias inherent to the single study described

Provenance

Source

paperswithcode

Collection Method

Experimental data from a laboratory study inducing severe acute pancreatitis in rats and administering pioglitazone.