Thiazole-Linked HDAC6 Inhibitors: Synthesis and Neuroplasticity Data

Compound 5h demonstrated potent HDAC6 inhibition with an IC50 of 25.56 nM and approximately 500-fold selectivity over HDAC1. The dataset, authored by Gibeom Nam and last updated in June 2026, contains results from docking simulations, gene expression analysis, and in vivo memory tests in mice. It supports research into novel therapeutic candidates for neurodegenerative diseases.

Use Cases

• Structure-activity relationship analysis based on synthesized thiazolyl hydroxamate derivatives.
• Molecular docking studies based on the described hydrophobic pocket interactions with HDAC6-specific residues.
• Evaluating therapeutic potential based on BDNF and neurogenesis-related gene upregulation data.
• Assessing in vivo efficacy based on memory performance results from the passive avoidance test.

Strengths

• Includes a specific, potent compound (5h) with an IC50 value of 25.56 nM.
• Provides a rationale for selectivity based on molecular docking and MD simulations.
• Contains multi-modal evidence from synthesis, in vitro assays, and in vivo behavioral tests.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect the specific experimental bias inherent to the figshare platform source.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from chemical synthesis, biological assays, and animal studies.

Freshness

Last updated 2026-06-04 18:05:54; freshness should be verified.