Rat Neonatal Cortex Data on Thyroid Hormone Insufficiency and Ca2+-Binding Proteins

Two studies (M1123 and M1224) where pregnant rats were dosed with Propylthiouracil (PTU) at concentrations of 0, 0.5, 1, and 3ppm. The dataset includes serum and cortical thyroid hormone measures, cortical gene expression, body weights, and immunohistochemical cell count data for parvalbumin, GAD-67, calbindin, and calretinin, along with periventricular heterotopia volume measures. The data was collected by the U.S. Environmental Protection Agency and last updated on 2026-03 14.

Use Cases

• Modeling dose-response relationships for thyroid hormone insufficiency based on PTU concentration levels.
• Analyzing correlations between serum thyroid hormone levels and cortical gene expression data.
• Investigating the impact of thyroid hormone on specific neuronal populations based on immunohistochemical cell counts for parvalbumin, calbindin, calretinin, and GAD-67.
• Studying structural brain abnormalities by analyzing periventricular heterotopia volume measures.

Strengths

• Includes data from two distinct experimental designs: a pilot study and a dose-response study.
• Measures multiple biological endpoints, including hormone levels (RIA and LC-MS/MS), gene expression (qPCR), body weights, cell counts, and brain volume.
• Cell counts and volume measures were conducted using specialized Aperio ImageScope software.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.
• Data may reflect experimental bias inherent to controlled animal studies.

Provenance

Source

U.S. Environmental Protection Agency

Collection Method

In vivo experimental studies on pregnant rats dosed with Propylthiouracil (PTU), with tissue collected from pups and dams.

Time Range

Temporal coverage is not explicitly stated in the input.

Freshness

Last updated 2026-03-14 10:21:47.212985; freshness should be verified.

Geography

Spatial coverage is not explicitly stated in the input.