Mouse Plasma N-Glycome Profiles Under Diet and Time-Dependent Drug Treatment

Plasma N-glycan profiles from mice reveal time-of-day-dependent changes influenced by a high-fat diet and the SGLT2 inhibitor dapagliflozin. The dataset contains quantitative glycomic measurements from a controlled experiment, with drug administration timed in the morning or at night. Yurika Ozawa published this research data on figshare in April 2026.

Use Cases

• Identify N-glycan features altered by high-fat diet feeding compared to control mice.
• Model the differential effects of morning versus nighttime dapagliflozin administration on glycan profiles.
• Correlate specific plasma N-glycan abundances with time-of-day sampling to study circadian influence.
• Test if glycan profiles serve as more sensitive biomarkers than blood glucose or body weight for drug effects.
• Analyze which HFD-induced glycan alterations are normalized by nighttime drug treatment.

Strengths

• Quantitative glycomic platform using glycoblotting and MALDI-TOF MS for precise measurement.
• Experimental design includes control, HFD, and two timed drug treatment groups for comparison.
• Data is structured in an XLSX file, facilitating direct analysis of glycan abundances and experimental conditions.

Limitations

• Small dataset size of 135.3 KB indicates limited sample count and scope.
• Data is from a mouse model, limiting direct translation to human physiology.
• Unknown row count and specific column structure hinders immediate assessment of data volume.

Provenance

Source

figshare, authored by Yurika Ozawa.

Collection Method

Data generated via a quantitative glycomic platform based on glycoblotting and MALDI-TOF mass spectrometry from mouse plasma samples.

Time Range

Covers the experimental period of the described study, specific dates not provided.

Freshness

Last updated in April 2026, indicating recent publication.