Neonatal Mouse Hyperoxia Data for Titrated BPD Severity Modeling

Gary Mouradian (Harvard Dataverse) released this dataset in 2026 containing raw physiological data points from neonatal mice. The data tracks the effects of titrated cumulative supplemental oxygen (CSO) to model varying severities of bronchopulmonary dysplasia (BPD).

Use Cases

• Correlating cumulative supplemental oxygen (CSO) levels with alveolar simplification severity
• Analyzing the relationship between hyperoxia and metabolic acidosis in neonatal subjects
• Evaluating pulmonary vascular medial wall thickening as a marker for pulmonary hypertension risk

Strengths

• Models both mild and severe BPD phenotypes using titrated oxygen levels
• Includes multi-system data covering respiratory, metabolic, and neural drive features
• Provides raw data points linked to peer-reviewed publication PMID: 41738294

Limitations

• Preclinical mouse model data may not fully represent human clinical BPD pathology
• Experimental window is limited to the saccular stage of lung development
• Controlled environment excludes common clinical complicating factors

Provenance

Source

Harvard Dataverse

Collection Method

laboratory experiment

Freshness

Last updated March 2026