TLR4 and LY96 Sequence Alignments for Evolutionary Analysis

A 91.7 KB collection of FASTA files containing aligned nucleotide sequences for the TLR4 gene and its co-receptor LY96 (MD-2). The data was sourced from BetaEnsembl and NCBI GeneBank, aligned using Aliview, and published under a CC-BY-4.0 license by Zijun He. The dataset was last updated on June 4, 2026.

Use Cases

• Perform branch-site analysis for positive selection using tools like aBSREL based on the TLR4 alignments.
• Identify conserved or variable regions within TLR4 sequences for functional studies.
• Conduct motif discovery and episodic selection analysis using the MEME method on the provided alignments.
• Prepare LY96 (MD-2) sequences for future comparative or co-evolutionary analysis with TLR4.

Strengths

• Data is explicitly sourced from authoritative genomic databases BetaEnsembl and NCBI GeneBank.
• The 91.7 KB size indicates a focused, manageable dataset for specific analyses.
• The CC-BY-4.0 license permits broad reuse and redistribution.

Limitations

• Row count and specific sequence identifiers are unknown, limiting suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description metadata is limited; actual data quality requires manual inspection.

Provenance

Source

BetaEnsembl and NCBI GeneBank

Collection Method

Sequences obtained from the listed databases and aligned using Aliview.

Freshness

Last updated 2026-06-04 22:07:43; freshness should be verified.