CAY-10746: Intraocular Pressure and Trabecular Meshwork Data from Normotensive Rats

Experimental data from a study evaluating the novel ROCK inhibitor CAY-10746 for glaucoma treatment. The dataset includes intraocular pressure measurements, histological images of trabecular meshwork morphology, and RNA sequencing results showing 762 differentially expressed genes. It was created by Menglong Hao and last updated in May 2026.

Use Cases

• Validate IOP-lowering drug efficacy based on concentration-dependent pressure reduction data.
• Analyze trabecular meshwork structural changes based on histological porosity measurements.
• Investigate glaucoma-related gene expression pathways based on RNA-Seq results for FN1, RHO, and CYP1B1.
• Assess drug cytotoxicity based on in vitro human trabecular meshwork cell tests.

Strengths

• Includes multiple data types: tabular IOP measurements, histological TIF images, and RNA-Seq results in XLS/XLSX files.
• Provides specific, statistically significant results: 25 µM dose produced robust IOP reduction for at least 8 hours (p < 0.001).
• Identifies 762 differentially expressed genes with pathway analysis for extracellular matrix and focal adhesion.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale ML tasks.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a single animal model (normotensive Sprague-Dawley rats), limiting generalizability.

Provenance

Source

figshare

Collection Method

Experimental study involving topical drug administration, rebound tonometry, histology, and RNA sequencing.

Freshness

Last updated 2026-05-07 09:55:48; freshness should be verified.