Ficus Virens Flavonoid Effects on Sepsis and Liver Injury in Mice

A research dataset from figshare by Yong Tang, last updated in April 2026, details a study on the protective effects of total flavonoids from Ficus virens leaves in a murine sepsis model. The 6.8 MB dataset includes PDF and DOCX files containing experimental results, such as survival rates, serum cytokine levels, and liver enzyme measurements. The data supports the investigation of botanical compounds for mitigating sepsis-induced inflammation and organ damage.

Use Cases

• Analyze the dose-response relationship of flavonoids on survival rates based on the described high-dose effect increasing survival from 12.5% to 50%.
• Model the anti-inflammatory effects based on described reductions in serum IL-6, TNF-α, and hepatic pro-inflammatory mediators.
• Investigate mechanisms of liver protection based on described modulation of ALT/AST enzymes, MDA, and SOD levels.
• Study signaling pathway inhibition based on the described suppression of TLR4/NLRP3 signaling and pyroptosis-associated proteins.

Strengths

• Specific quantitative results are reported, such as a survival rate increase from 12.5% to 50%.
• The dataset includes measurements for multiple biomarkers, including IL-6, TNF α, ALT, AST, MDA, and SOD.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset consists of PDF and DOCX files, which may require manual extraction for computational analysis.
• The data is from a single study on a mouse model, limiting generalizability.

Provenance

Source

Yong Tang via figshare.

Collection Method

Experimental data from a murine sepsis model induced by LPS injection.

Time Range

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Freshness

Last updated 2026-04-10 21:20:03.

Geography

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