Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target (Tibia
Updated 3mo ago
3filesBIN
Available on 1 platform
Sign in to view source links and access this dataset
Description
NASA examined the effects of approximately 30 days of spaceflight on glycogen synthase kinase 3 (GSK3) in murine muscle and bone samples from four separate missions (BION-M1, RR1, RR9, RR18). This specific dataset derives from the Western blot assay using tibialis anterior tissue from the RR9 mission, with results linked to related studies on other tissues. The data was last updated on March 13, 2026.
Use Cases
Modeling the relationship between GSK3 content and muscle fiber type shifts based on mission-specific findings.
Analyzing the inhibitory serine phosphorylation of GSK3 in response to spaceflight across different missions.
Investigating the potential of GSK3 inhibition as a countermeasure for spaceflight-induced muscle and bone loss.
Correlating muscle-specific Gsk3 knockdown data with changes in muscle mass and bone mineral density from hindlimb unloading experiments.
Strengths
Data originates from four separate spaceflight missions (BION-M1, RR1, RR9, RR18), providing comparative context.
Results are linked to five other related studies (OSD-654 to OSD-664) using tissues from the same experiment.
The dataset is provided by the authoritative source, the National Aeronautics and Space Administration (NASA).
Limitations
Column-level documentation is absent; field semantics must be inferred after download.
Row count and sample size are unknown, which may limit suitability assessment.
The data format is listed as 'BIN', which may require specific tools for access and analysis.
Provenance
Source
National Aeronautics and Space Administration
Collection Method
Western blot assay performed on tibialis anterior tissue from the Rodent Research 9 (RR9) spaceflight mission.
Time Range
Temporal coverage of the underlying experiments is not specified.
Freshness
Last updated 2026-03-13 19:58:41.246299; freshness should be verified.
Geography
Spatial coverage is not specified; research is related to spaceflight.
License is listed as 'other-license-specified'; users must inspect the specific terms before use.