Toxicity Reference Database of 474 Chemicals from EPA Studies

The Toxicity Reference Database (ToxRefDB) from the U.S. Environmental Protection Agency contains toxicity testing results for 474 chemicals, primarily pesticide active ingredients. It consolidates approximately 30 years and $2 billion worth of animal studies previously found only in paper documents.

Use Cases

• Analyze toxicity endpoints across the 474 listed chemicals to identify common hazard profiles.
• Study the distribution of chemical types, such as pesticide active ingredients, within the database for regulatory review.
• Use the compiled animal study results to benchmark new chemical safety assessments against historical data.

Strengths

• Contains data from approximately 30 years of animal toxicity studies.
• Represents an estimated $2 billion worth of research investment.
• Focuses on 474 well-defined chemicals, primarily pesticide active ingredients.

Limitations

• The specific data columns, row counts, and file formats are not provided, limiting understanding of the data structure.
• The database's growth is noted, but the current scope of 474 chemicals may be limited for broad chemical space analysis.
• Data recency is unclear as the last platform update was in 2020.

Provenance

Source

U.S. Environmental Protection Agency

Collection Method

Consolidation of historical animal toxicity testing results from paper documents.

Time Range

Approximately 30 years of studies (specific range not provided).

Freshness

Last platform update was 2020-12-03; update frequency is unknown.

Geography

Primarily United States (inferred from organization and tags).