Feline Alimentary Lymphoma Transcriptomics for 19 Cases Across Five Subtypes

RNA sequencing data from 19 cases of feline alimentary lymphoma, split into five phenotypes: small T cell, B cell, CD56+ B cell, Large Granular T cell, and Large Granular NK cell lymphomas. The dataset, authored by Chiara Palmieri and last updated in April 2026, applies differential gene analysis to identify genes correlated with lymphoma aggressiveness. It highlights overexpression of genes involved in extracellular matrix remodelling, transcription, and cellular division in aggressive types, and tumour suppressor genes in indolent types.

Use Cases

• Identify biomarkers for lymphoma aggressiveness based on differential expression of genes like ADAMTS14, FOXI3, and CENPF.
• Compare gene expression profiles across five distinct lymphoma phenotypes (e.g., small T cell vs. B cell).
• Investigate pathways related to extracellular matrix remodelling and cellular metabolism in feline cancer.
• Validate potential tumour suppressor genes such as RAB17 and GRM4 in indolent lymphoma subtypes.

Strengths

• Dataset includes RNA-seq data from 19 distinct clinical cases.
• Analysis covers five specific lymphoma phenotypes defined by histomorphology and immunohistochemistry.
• Specific differentially expressed genes are named, including ADAMTS14, CCR1, and IGF2BP3 for aggressive types and RAB17 for indolent types.
• Available under a permissive CC-BY-4.0 license.

Limitations

• The dataset is very small at 56.9 KB, suggesting limited scope.
• Row count and column-level documentation are unknown; field semantics must be inferred after download.
• Data may reflect sample collection bias inherent to the specific veterinary study.

Provenance

Source

figshare, author Chiara Palmieri.

Collection Method

RNA sequencing data from clinical cases, with phenotypes assigned via histomorphology and immunohistochemistry.

Freshness

Last updated 2026-04-14 05:05:55; freshness should be verified.