Human Fibroblast Gene Expression Changes in Spaceflight

NASA conducted an experiment on the International Space Station to test hypotheses about altered microRNA profiles and cellular responses to DNA damage in a microgravity environment. The dataset likely contains gene expression profile changes of confluent human fibroblast cells. The data was last updated in March 2026.

Use Cases

• Identify differentially expressed genes in microgravity based on the described gene expression profile changes.
• Analyze the role of microRNAs in spaceflight-induced cellular changes based on the hypothesis about altered miRNA profiles.
• Compare cellular DNA damage responses in space versus on the ground based on the experiment's stated objective.
• Model gene regulatory networks affected by spaceflight based on the described influence on global gene expression patterns.

Strengths

• Data originates from a controlled experiment on the International Space Station, providing a unique environment.
• The dataset description explicitly outlines the scientific hypotheses being tested.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is stored in a BIN format, which may require specialized tools for access and analysis.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experiment conducted on the International Space Station, likely involving RNA sequencing.

Freshness

Last updated 2026-03-13 19:24:12.358956; freshness should be verified.

Geography

International Space Station (Low Earth Orbit)