Two Amide Alkaloids from Portulaca Oleracea and Their Bioactivities

Zhiwei Zhang's research on figshare, last updated April 30, 2026, details the isolation and characterization of two novel alkaloids from the plant Portulaca oleracea L. The 22.3 MB dataset includes PDF and DOCX files reporting the chemical structures determined via NMR and UHPLC-ESI-QTOF/MS analysis. The compounds Oleracrylimide I and J demonstrated potent anti-inflammatory activity by suppressing IL-1β and TNF-α release at concentrations of 10 μM and 5 μM.

Use Cases

• Identifying novel anti-inflammatory compounds based on the reported bioactivity data.
• Studying the structure-activity relationship of amide alkaloids based on the elucidated chemical structures.
• Developing computational models for natural product discovery based on the spectroscopic characterization methods described.

Strengths

• Includes detailed structural elucidation data from NMR and UHPLC-ESI-QTOF/MS techniques.
• Reports specific, quantitative bioactivity results (suppression of IL-1β and TNF-α at 10 μM and 5 μM).
• Released under a CC-BY-4.0 license, permitting broad reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Phytochemical investigation and spectroscopic analysis of plant material.

Time Range

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Freshness

Last updated 2026-04-30 14:40:04; freshness should be verified.

Geography

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