A research dataset from the paper 'Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/alpha-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy' by Lijie Feng, published on the Papers with Code platform. The data likely contains experimental results on the mechanisms of protein degradation for the misfolded SERPINA1 Z variant, which is associated with alpha-1-antitrypsin deficiency and liver injury. The dataset is available under an Open Access (green) license.
Use Cases
- Modeling protein degradation pathways based on the interaction between SYVN1 and SERPINA1 Z variant described in the study.
- Analyzing ubiquitination patterns based on the described K48-linked polyubiquitin chains conjugated onto SERPINA1 Z variant.
- Studying selective autophagy mechanisms based on the described role of the SQSTM1/p62 protein in forming the autophagy complex.
- Investigating cytotoxicity suppression based on the described effect of SYVN1 and autophagy inducers on SERPINA1 Z variant-induced cell apoptosis.
Strengths
- Dataset is associated with a specific, peer-reviewed research paper describing a novel biological mechanism.
- The description provides a detailed biological context for the SERPINA1 Z variant and its link to liver disease.
- The data is available under an Open Access (green) license, facilitating reuse.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- Last update date is unknown; freshness unverified.
Provenance
- Source
- Papers with Code platform, associated with the research paper by Lijie Feng.
- Collection Method
- Likely contains experimental data generated from the described molecular biology study.