Systems serology profiles from 182 individuals track antibody isotypes and Fc-mediated effector functions against HPV16 E2 and E7 antigens in oropharyngeal squamous cell carcinoma (OPSCC) patients. Developed by Vicky Roy and hosted on Harvard Dataverse, the data includes longitudinal observations spanning over 700 days across diagnosis, treatment, and recurrence phases.
Use Cases
- Predicting recurrence risk using E2-specific Fc-functional signatures
- Modeling the longitudinal decay of IgG1-dominated responses over 700 days
- Classifying patient status (diagnosis vs. recurrence) based on complement-fixing antibody levels
Strengths
- Longitudinal tracking for >700 days
- 182 distinct individuals profiled
- Includes functional Fc-effector activity labels beyond simple antibody magnitude
Limitations
- Small sample size of 182 individuals
- Potential geographic bias as data comes from a single institutional source
- Focus limited to HPV16 E2 and E7 antigens
Provenance
- Source
- Vicky Roy, Harvard Dataverse
- Collection Method
- Systems serology profiling and clinical observation
- Time Range
- Up to 700 days post-treatment
- Freshness
- Last updated March 2026.