MVTs: Antibacterial Activity of Metronidazole-Berberine Conjugates

A dataset likely contains results from medicinal chemistry experiments on novel antibacterial compounds. The data describes the synthesis and testing of metronidazolyl vinylthiazolidionyl tetrahydroberberines (MVTs), including minimum inhibitory concentrations (MICs), hemolysis, cytotoxicity, and biofilm eradication assays. The dataset was authored by Yu Zhou and last updated on 2026-05-26.

Use Cases

• Compare antibacterial potency based on reported MIC values against specific pathogens like S. aureus 25923.
• Analyze drug safety profiles based on hemolysis and cytotoxicity data mentioned in the description.
• Evaluate biofilm eradication efficacy as described for the lead compound MVT 7b.
• Study mechanisms of action based on described multi-targeting effects including membrane disruption and oxidative stress.

Strengths

• Includes specific quantitative results, such as an MIC of 0.005 mM for compound 7b against S. aureus 25923.
• Describes multiple assay types, including antibacterial activity, hemolysis, cytotoxicity, and biofilm eradication.
• Provides comparative potency data, showing compound 7b was 3-fold and 69-fold more active than norfloxacin and berberine respectively.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last updated 2026-05-26 08:05:49; freshness should be verified.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from medicinal chemistry and biological assays.