Myoepithelial Cell Transcriptomics from Seven Human Breast Cancer Specimens

A transcriptomic analysis of myoepithelial cells isolated from seven archived human breast cancer specimens and adjacent normal tissue. The dataset includes gene expression changes related to extracellular matrix interactions, epithelial-mesenchymal transition, and cellular signaling. It was authored by Mohamed M. Haq and last updated on 2026-05-12.

Use Cases

• Identify gene expression signatures associated with cancer progression based on transcriptomic reprogramming.
• Study extracellular matrix remodeling based on the overexpression of 17 distinct collagen genes.
• Analyze epithelial-mesenchymal transition markers based on dysregulation of keratins (KRT5, KRT7, KRT14).
• Investigate tumor-promoting mediators based on increased expression of SPARC, POSTN, and integrin subunits.

Strengths

• Direct comparison of myoepithelial cells from cancer and adjacent normal tissue from seven specimens.
• Analysis covers three key biological domains: ECM interactions, EMT, and cellular signaling.
• Specific molecular findings are reported, including 17 collagen genes and MMPs 2, 9, 11, and 14.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The sample size is limited to seven specimens, as noted in the description.

Provenance

Source

figshare

Collection Method

Transcriptomic analysis performed on isolated myoepithelial cells from archived human breast cancer specimens.

Freshness

Last updated 2026-05-12 11:03:12; freshness should be verified.