UGT1A8 Fluorescent Probe Data for Inhibitor Screening

UPro^1A8 is a dataset containing structural and screening data for a novel fluorescent probe targeting the human metabolic enzyme UGT1A8. The dataset includes results from screening a compound library, identifying four natural products as potent inhibitors. Xin-Fang Zhai published this dataset on figshare in April 2026.

Use Cases

• Identify UGT1A8 inhibitors by analyzing the probe's response to compounds like Ginkgetin and Silibinin.
• Validate probe selectivity metrics against other UGT isoforms for assay development.
• Use the probe's structural data to model UGT1A8 binding sites and inhibitor interactions.
• Apply the screening results to study the role of UGT1A8 in endometrial and breast cancer pathogenesis.

Strengths

• Probe demonstrates excellent selectivity for UGT1A8 over other UGT isoforms.
• Screening identified four specific natural product inhibitors: Ginkgetin, Silibinin, Ledebouriellol, and Antcin C.

Limitations

• The dataset is small, at 537.5 KB, indicating limited scope and likely a single experiment.
• No column names or sample data are provided, limiting immediate analysis.
• The data is focused on a single, novel probe, which may not be generalizable to other UGT1A8 research tools.

Provenance

Source

Xin-Fang Zhai via figshare.

Collection Method

Data was generated through the development and application of the UPro^1A8 fluorescent probe, including selectivity tests and compound library screening.

Time Range

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Freshness

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Geography

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