UGT1A8 Enzyme Inhibitor Screening Data via Fluorescent Probe

UPro^1A8 is a specific fluorescent probe for the human metabolic enzyme UGT1A8, developed by Xin-Fang Zhai and published in 2026. The dataset includes results from screening a compound library, identifying four natural products as potent inhibitors. The data supports functional imaging and inhibitor evaluation in living cells, tissue slices, and zebrafish models.

Use Cases

• Identify UGT1A8 inhibitors by screening compound library data for compounds like Ginkgetin and Silibinin.
• Validate probe selectivity using data comparing UGT1A8 activity against other UGT isoforms.
• Analyze inhibitor potency from evaluation data generated in living cells and tissue slices.
• Correlate fluorescent probe signal intensity with endogenous UGT1A8 activity levels in zebrafish models.

Strengths

• Probe validated for excellent selectivity and sensitivity for UGT1A8 over other isoforms.
• Screening identified four specific natural product inhibitors: Ginkgetin, Silibinin, Ledebouriellol, and Antcin C.

Limitations

• Dataset is very small at 537.5 KB, indicating limited scope and likely a focused experimental result set.
• No explicit row or column counts are provided, making the data's granularity and feature set unclear.
• Application is highly specific to the UGT1A8 enzyme, limiting generalizability to other metabolic pathways.

Provenance

Source

figshare, authored by Xin-Fang Zhai.

Collection Method

Experimental development of a fluorescent probe and subsequent compound library screening.

Time Range

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Freshness

Last updated in April 2026.

Geography

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