UGT1A8 Fluorescent Probe Data for Inhibitor Screening

UPro1A8 is a fluorescent probe designed for selective real-time monitoring of the human metabolic enzyme UGT1A8. The dataset contains results from screening a compound library, which identified four natural products as potent UGT1A8 inhibitors. The data was published by Xin-Fang Zhai in 2026.

Use Cases

• Identify UGT1A8 inhibitors by analyzing fluorescence intensity data from the compound library screening.
• Validate probe selectivity by comparing activity data for UGT1A8 against other UGT isoforms.
• Assess inhibitor potency using dose-response or inhibition percentage data derived from the probe assay.
• Correlate chemical structures of identified inhibitors (e.g., Ginkgetin, Silibinin) with their inhibitory activity metrics.

Strengths

• Probe validated for selectivity across multiple UGT isoforms.
• Data enables real-time visualization in living cells, tissue slices, and zebrafish models.
• Identifies four specific natural product inhibitors (Ginkgetin, Silibinin, Ledebouriellol, Antcin C).

Limitations

• Dataset is very small at 22.2 KB, indicating limited scope.
• Specific row count, column names, and experimental replicates are unknown.
• Findings are based on a specific probe technology and may not generalize to other assay methods.

Provenance

Source

Figshare, authored by Xin-Fang Zhai.

Collection Method

Experimental data from developing and applying the UPro1A8 fluorescent probe for inhibitor screening.

Freshness

Last updated in April 2026.