V-safe COVID-19 Vaccine Side Effect Surveillance Data

Encompassing enrollment, vaccination information, and daily and weekly surveys from the V-safe active safety surveillance system, collected from January 22, 2024, to March 23, 2025. The data is self-reported by voluntary participants in the U.S. and is managed by the U.S. Department of Health & Human Services.

Use Cases

• Analyze self-reported side effects from daily and weekly surveys to characterize post-vaccination symptom patterns.
• Link enrollment data with vaccination information files to study participant demographics and vaccine manufacturer details.
• Examine survey completion rates and potential attrition over time using the time-stamped survey data.
• Compare corrected vaccination records in the 'Vaccination' file with old records to assess data quality and update processes.

Strengths

• Data collection spans over 14 months, from January 2024 to March 2025.
• Includes multiple data components: enrollment files, vaccination information, and daily/weekly surveys.
• Managed by the U.S. Department of Health & Human Services, providing an authoritative public health source.

Limitations

• Data is self-reported, which may lead to misclassification of outcomes, vaccine details, or demographics.
• The voluntary, smartphone-based enrollment means the sample is not representative of the full U.S. vaccinated population.
• Missing data may exist due to participant-requested corrections, system outages, or survey attrition over time.

Provenance

Source

U.S. Department of Health & Human Services.

Collection Method

Voluntary self-enrollment via smartphone, with data collected through daily and weekly surveys.

Time Range

January 22, 2024, to March 23, 2025.

Freshness

Data was last updated on March 20, 2026.

Geography

United States.