Valproic Acid Effects on Stress-Induced Depression in Rodent Models

A systematic review and meta-analysis of 16 experiments from the Forced Swimming Test, 7 from the vertical Open Field Test, and 9 from the Sucrose Preference Test. Mina Goudarzi compiled this data to assess the antidepressant-like effects of Valproic acid in rat models of stress-induced depression. The analysis includes standardized mean differences, confidence intervals, and p-values for behavioral test outcomes.

Use Cases

• Analyze the relationship between Valproic acid dosage (300 mg/kg/day) and Forced Swimming Test immobility percentage across 16 experiments.
• Compare movement score outcomes from the vertical and horizontal Open Field Test data across 13 total studies.
• Model the effect of Valproic acid on sucrose preference scores using data extracted from 9 separate Sucrose Preference Test experiments.
• Investigate heterogeneity and potential publication bias mentioned in the meta-analysis findings.

Strengths

• Meta-analysis includes quantitative results from 16 Forced Swimming Test experiments.
• Data extracted from four standardized behavioral tests: FST, OFT, NOR, and SPT.
• Analysis reports specific statistical measures including standardized mean differences, 95% confidence intervals, and p-values.

Limitations

• Dataset is very small (215.7 KB), containing a review document rather than a primary data table.
• The authors note heterogeneity and potential publication bias in the underlying studies.
• No raw experimental data or columnar structure is provided; data is presented in narrative and statistical summary form.

Provenance

Source

figshare, author Mina Goudarzi.

Collection Method

Systematic review and meta-analysis of published articles, conducted using Stata 14.

Time Range

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Freshness

Last updated March 2026.

Geography

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