Coxiella Burnetii SCV-Like Form Data from Hypoxic Macrophage Infections

274.7 MB of experimental data from figshare details how Coxiella burnetii, the Q fever bacterium, survives adverse conditions. The dataset, authored by Jan Schulze-Lührmann and last updated in April 2026, likely contains measurements from primary murine macrophages infected under normoxic and hypoxic conditions. It suggests the bacterium enters a smaller, more infectious SCV-like persistent form to thrive once conditions improve.

Use Cases

• Modeling bacterial survival strategies based on hypoxia-induced citrate limitation mentioned in the description
• Analyzing changes in bacterial morphology and infectivity based on the SCV-like form characteristics
• Investigating antibiotic tolerance mechanisms based on the described resistance of the persistent form
• Studying immune evasion based on the reduced sensitivity to clearance by IFNg activated macrophages

Strengths

• Data size is 274.7 MB, indicating a medium-scale dataset with substantial content
• Includes multiple file formats (PDF, TXT, XLSX) for varied analysis approaches
• Released under a permissive CC-BY-4.0 license for broad reuse
• Based on experimental infection of primary macrophages, a biologically relevant model

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare

Collection Method

Experimental data from infection of primary murine macrophages under controlled oxygen conditions.

Time Range

Experimental timeframe not specified; dataset updated April 2026.

Freshness

Last updated 2026-04-24 12:37:52; freshness should be verified

Geography

Geographic origin of data or samples is not specified.