VK4-40: Rodent Cocaine Self-Administration and Relapse Data

Experimental data from a study evaluating the novel D3 receptor partial agonist VK4-40 on cocaine-related behaviors in rats. The dataset likely contains results from intravenous self-administration, cocaine-primed reinstatement, optogenetic brain-stimulation reward, and conditioned place preference tests. The research was conducted by Chloe J. Jordan of the National Institute on Drug Abuse.

Use Cases

• Train models to predict drug-seeking behavior based on pharmacological intervention data.
• Analyze dose-response relationships for novel therapeutics in addiction research.
• Compare behavioral outcomes across different experimental paradigms like self-administration and reinstatement.

Strengths

• Data is derived from controlled, multi-paradigm experimental procedures including self-administration and optogenetics.
• Study evaluates a specific, novel compound (VK4-40) with reported selectivity and metabolic stability.

Limitations

• Row count and specific column-level documentation are absent, limiting suitability assessment.
• Data is limited to rodent models; direct applicability to human clinical outcomes is unknown.

Provenance

Source

National Institute on Drug Abuse

Collection Method

Experimental data from rodent studies using intravenous self-administration, optogenetic stimulation, and behavioral paradigms.